Prokaryotic_initiation_factor-2

Bacterial initiation factor 2

Bacterial initiation factor 2

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Bacterial initiation factor-2 is a bacterial initiation factor.[1]

Quick Facts Translation initiation factor IF-2, bacterial-like, Identifiers ...

IF2 binds to an initiator tRNA and controls the entry of tRNA onto the ribosome. IF2, bound to GTP, binds to the 30S P site. After associating with the 30S subunit, fMet-tRNAf binds to the IF2 then IF2 transfers the tRNA into the partial P site. When the 50S subunit joins, it hydrolyzes GTP to GDP and Pi, causing a conformational change in the IF2 that causes IF2 to release and allow the 70S ribosome to form.

Human mitochondria use a nuclear-encoded homolog, MTIF2, for translation initiation.[2]

References

  1. [1]
    Prokaryotic+Initiation+Factor-2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  2. [2]
    D'Souza AR, Minczuk M (July 2018). "Mitochondrial transcription and translation: overview". Essays in Biochemistry. 62 (3): 309–320. doi:10.1042/EBC20170102. PMC 6056719. PMID 30030363.
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