In enzymology, a propanediol-phosphate dehydrogenase (EC 1.1.1.7) is an enzyme that catalyzes the chemical reaction

propane-1,2-diol 1-phosphate + NAD⁺ ${\displaystyle \rightleftharpoons }$ hydroxyacetone phosphate + NADH + H⁺

Thus, the two substrates of this enzyme are propane-1,2-diol 1-phosphate and NAD⁺, whereas its 3 products are hydroxyacetone phosphate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is propane-1,2-diol-1-phosphate:NAD⁺ oxidoreductase. Other names in common use include PDP dehydrogenase, 1,2-propanediol-1-phosphate:NAD⁺ oxidoreductase, and propanediol phosphate dehydrogenase.