Protein_N-acetylglucosaminyltransferase

Protein N-acetylglucosaminyltransferase

Protein N-acetylglucosaminyltransferase

Class of enzymes

In enzymology, a protein N-acetylglucosaminyltransferase (EC 2.4.1.94) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + protein UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein
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Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and protein, whereas its two products are UDP and 4-N-(N-acetyl-D-glucosaminyl)-protein.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase. Other names in common use include uridine diphosphoacetylglucosamine-protein, acetylglucosaminyltransferase, uridine diphospho-N-acetylglucosamine:polypeptide, beta-N-acetylglucosaminyltransferase, and O-GlcNAc transferase.

References

    • Khalkhall Z, Marshall RD (1975). "Glycosylation of ribonuclease A catalysed by rabbit liver extracts". Biochem. J. 146 (2): 299–307. PMC 1165306. PMID 1156375.
    • Khalkhali Z, Marshall RD (1976). "UDP-N-acetyl-D-glucosamine-asparagine sequon N-acetyl-beta-D-glucosaminyl-transferase-activity in human serum". Carbohydr. Res. 49: 455–73. doi:10.1016/S0008-6215(00)83163-8. PMID 986874.
    • Khalkhali Z, Marshall RD, Reuvers F, Habets-Willems C, Boer P (1976). "Glycosylation in vitro of an asparagine sequon catalysed by preparations of yeast cell membranes". Biochem. J. 160 (1): 37–41. PMC 1164198. PMID 795426.


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