60S ribosomal protein L7a is a protein that in humans is encoded by the RPL7A gene.^[5][6][7]

Quick Facts RPL7A, Available structures ...

RPL7A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL7A, L7A, SURF3, TRUP, ribosomal protein L7a
External IDs	OMIM: 185640 MGI: 1353472 HomoloGene: 105462 GeneCards: RPL7A
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.2 Start 133,348,218 bp[1] End 133,351,426 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 19.1 cM Start 26,800,776 bp[2] End 26,803,330 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans right uterine tube right adrenal gland smooth muscle tissue pituitary gland rectum anterior pituitary zone of skin body of pancreas skin of abdomen Top expressed in ganglionic eminence uterus ovary esophagus lip lens ileum colon zone of skin thymus More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding cadherin binding RNA binding Cellular component cytoplasm cytosol ribosome membrane focal adhesion nucleolus cytosolic large ribosomal subunit extracellular exosome nucleus polysomal ribosome ribonucleoprotein complex Biological process ribosome biogenesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing maturation of LSU-rRNA protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6130 27176 Ensembl ENSG00000280858 ENSG00000148303 ENSMUSG00000062647 UniProt P62424 P12970 RefSeq (mRNA) NM_000972 NM_013721 RefSeq (protein) NP_000963 NP_038749 Location (UCSC) Chr 9: 133.35 – 133.35 Mb Chr 2: 26.8 – 26.8 Mb PubMed search [3] [4]
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Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]