A Regional Security Office is the office at a U.S. Embassy or Consulate that oversees all functions of security. It is headed by a special agent of the U.S. Diplomatic Security Service (DSS) who has the title of Regional Security Officer (RSO).

The employees of a Regional Security Office are responsible for the safety and security of all Americans at post. This includes managing security for official buildings, as well as residences.

Within a Regional Security Office, and under its RSO, may be found Assistant RSOs, Office Management Specialists and other assistants. In addition, the Engineering Services Center/Office, and the Marine Security Guard detachment office, which report through the RSO, are considered to be sub-units of the Regional Security Office.

The U.S. Diplomatic Security Service is the most widely represented law enforcement organizations in the world;^{[clarification needed]} it has the capability to track and capture fugitives who have fled U.S. jurisdiction to avoid prosecution.^{[citation needed]} During 2009, DSS assisted in the resolution of 136 international fugitive cases from around the globe.^[1]

• Ramzi Yousef - captured by U.S. Diplomatic Security utilizing Rewards for Justice (RFJ)
• Rewards for Justice - money for information leading to the capture of terrorists, administered by U.S. Diplomatic Security