Resident Evil: Vendetta, known as Biohazard: Vendetta (バイオハザード ヴェンデッタ, Baiohazādo Vendetta) in Japan, is a 2017 English-language Japanese computer-animated adult animated biopunk action horror film set in the same universe as the Resident Evil video games. Produced by Marza Animation Planet and Capcom producer Hiroyuki Kobayashi, the film features the characters Leon S. Kennedy, Chris Redfield, and Rebecca Chambers. Takashi Shimizu also served as executive producer, and Capcom producer Hiroyuki Kobayashi supervised the film. It is the third CG film, preceded by Resident Evil: Degeneration (2008) and Resident Evil: Damnation (2012), and also the third film installment with Leon Kennedy as a main character. It was released in Japan on May 27, 2017. A sequel, Resident Evil: Death Island, was released in 2023.

In 2014,^{[lower-alpha 1]} BSAA agent Chris Redfield is tracking Glenn Arias, a former CIA operative-turned arm's dealer. Arias, wanting revenge against the U.S. government for killing his friends and family in a drone strike at his wedding, is developing and smuggling bioweapons into the country, so Chris and other agents infiltrate a mansion in Mexico, to rescue their missing undercover source, Cathy White. There, Chris's fellow agents are ambushed by zombies and death traps, with Chris being the sole survivor. Outside the mansion, Chris faces Arias, who reveals that Cathy has become a zombie under his control. As Arias leaves with his associates, father and daughter Diego and Maria Gomez, the BSAA rescues Chris by slaughtering Cathy and the remaining zombie horde.

Four months later, Professor Rebecca Chambers, former S.T.A.R.S. unit member and survivor of the Mansion Incident, studies the new "Animality Virus"—"A-virus" for short—that can lay dormant inside any individual until the right trigger is presented. The virus has three components: the base virus, the triggering virus, and the vaccine. Maria attacks the research labs and releases the virus via the aerosol form. While her colleagues turn into zombies, Rebecca formulates a vaccine to make herself immune and is eventually rescued by Chris and his BSAA team: D.C., Damian, and Nadia. He briefs her on his mission.

Rebecca recognizes the zombies' loyalty to the host and makes a connection to Las Plagas, the bioweapon used by the Los Illuminados who Division of Security Operations (DSO) agent Leon S. Kennedy once encountered in Europe, theorizing that the remaining members of the cult are providing information to Arias in developing the A-virus. They will contact Leon in Colorado to get him on board. However, a guilt-ridden Leon is unwilling at first after having had to kill the SWAT team sent to back him up during a bomb threat, which turned out to be a small viral outbreak. Leon wonders how long they can keep fighting the BOWs and the people who create them like they have been for years. During this conversation, Maria and Diego attack the trio. They successfully capture Rebecca, while Chris and Leon, who agree to help finish the mission, devise a rescue operation, decrypting Arias's plan of a large-scale viral attack on New York City.

Another part of Arias' plan is to finish his aborted wedding and make Rebecca his bride, as she resembles his late wife. To that end, Arias develops a new strain of the A-virus that resists Rebecca's vaccine and injects it into her, saying it will fully take effect after twenty minutes.

Arias then challenges Chris to rescue Rebecca within that time frame. As Arias's associates initiate their attack on New York by releasing the virus-laden gas via tankers, Leon and Chris's BSAA team destroy the vehicles, contain the virus, and incapacitate Maria in the process, although Damian is killed by zombie dogs in the process. Chris, later joined by Leon, then infiltrates Arias's safe house, defeats Diego, and rescues Rebecca. On the terrace, Chris engages Arias in combat and throws him through a glass terrace to his demise. Diego then arrives and, despite being badly injured after being defeated by Chris, merges with Arias to form a new Tyrant monster. Chris is no match against the Tyrant until Leon joins the fight after working through the safe house, mowing down zombies. With the assistance of D.C. and Nadia, they trap the Tyrant before Leon and Chris kill it. They locate the antidote that Arias kept and cure Rebecca before escaping by helicopter. The team then spreads the antidote across the city to cure the rest of the infected. Meanwhile, Maria, later revealed to be alive, discovers her now-dead father.

On October 15, 2015, Marza Animation Planet announced that they "decided to make a full-length CG animation movie" of Resident Evil series, which was referred to as a "reboot" and was set to be released in 2017.^[5] The title of the work-in-progress Resident Evil film was revealed as Resident Evil: Vendetta on March 25, 2016. In addition, a new promotional picture was released by Italian motorcycle manufacturer Ducati and the film studio at the 43rd Tokyo Motorcycle Show, showcasing Leon Kennedy with Ducati's newest XDiavel model motorcycle as part of an advertising agreement. In the film, Leon rides a Ducati XDiavel during the "action-packed scenes and at the climax of the movie".^{[6][7][8][9][10]} Capcom stated that despite being called a reboot, it is still actually just a sequel. They were actually referring to the film's new tone.^[11] The first trailer was released during the Tokyo Game Show on September 17, 2016, along with new footage of Resident Evil 7: Biohazard.^[12][13]

Capcom Producer Hiroyuki Kobayashi wanted Leon be the main character, while the film producers wanted Chris to be the lead; in the end, both were used. Kobayashi also suggested that Rebecca Chambers be included, marking her return to the franchise, which was accepted. Since had not been part of a Resident Evil story in a while, the team used the opportunity to explore how she'd matured in the intervening time.^[14] The chase scene between Leon and dogs was almost removed from the film, but director Takanori Tsujimoto pushed for it to be kept.^[15]

To promote the film, a virtual reality experience for PlayStation VR, titled Resident Evil: Vendetta – Infected Experience, was released on May 24, 2017, for free.^[16] Resident Evil: Vendetta was released in Japanese theaters on May 27, 2017,^[17] after a premiere in Shinjuku on May 26.^[18] A limited theatrical showing in United Kingdom took place on June 14, 2017, and Fathom Events held a special one-night showing of the film across select theaters in North America on June 19, 2017.^[19] The film became available in North America across digital retailers on June 20 and on Ultra HD Blu-ray, Blu-ray and DVD on July 18 through Sony Pictures Home Entertainment, under the Stage 6 Films banner.^[20][21] The original soundtrack composed by Kenji Kawai was released on July 7, 2017, through iTunes Store.^[22] On September 6, 2017, the film was released on Ultra HD Blu-ray, Blu-ray and DVD in Japan.^[23][24][25]

On February 7, 2023, IGN released a teaser trailer for Resident Evil: Death Island, which is a sequel to Vendetta. It was theatrically released in the summer of 2023.^[34] It also received a physical and digital release on July 25th, 2023.

• List of films based on video games