In the mathematical field of knot theory, a chiral knot is a knot that is not equivalent to its mirror image (when identical while reversed). An oriented knot that is equivalent to its mirror image is an amphicheiral knot, also called an achiral knot. The chirality of a knot is a knot invariant. A knot's chirality can be further classified depending on whether or not it is invertible.

There are only five knot symmetry types, indicated by chirality and invertibility: fully chiral, invertible, positively amphicheiral noninvertible, negatively amphicheiral noninvertible, and fully amphicheiral invertible.^[1]

The possible chirality of certain knots was suspected since 1847 when Johann Listing asserted that the trefoil was chiral,^[2] and this was proven by Max Dehn in 1914. P. G. Tait found all amphicheiral knots up to 10 crossings and conjectured that all amphicheiral knots had even crossing number. Mary Gertrude Haseman found all 12-crossing and many 14-crossing amphicheiral knots in the late 1910s.^[3][4] But a counterexample to Tait's conjecture, a 15-crossing amphicheiral knot, was found by Jim Hoste, Morwen Thistlethwaite, and Jeff Weeks in 1998.^[5] However, Tait's conjecture was proven true for prime, alternating knots.^[6]

• Both possible trefoil knots.
• 
  The left-handed trefoil knot.
• 
  The right-handed trefoil knot.

The simplest chiral knot is the trefoil knot, which was shown to be chiral by Max Dehn. All nontrivial torus knots are chiral. The Alexander polynomial cannot distinguish a knot from its mirror image, but the Jones polynomial can in some cases; if V_k(q) ≠ V_k(q⁻¹), then the knot is chiral, however the converse is not true. The HOMFLY polynomial is even better at detecting chirality, but there is no known polynomial knot invariant that can fully detect chirality.^[7]

An amphicheiral knot is one which has an orientation-reversing self-homeomorphism of the 3-sphere, α, fixing the knot set-wise. All amphicheiral alternating knots have even crossing number. The first amphicheiral knot with odd crossing number is a 15-crossing knot discovered by Hoste et al.^[6]