Route 51 is a highway in southeastern Missouri. Its northern terminus is the Illinois state line near Chester, Illinois; its southern terminus is at the Arkansas state line northwest of Piggott, Arkansas. It continues into Illinois as Illinois Route 150 and it continues into Arkansas as Highway 139.

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Quick Facts Route 51, Route information ...

Route 51
Route information
Maintained by MoDOT
Length	120.811 mi[1] (194.426 km)
Existed	1922–present
Major junctions
South end	AR 139 at the Arkansas state line
Major intersections	Future I-57 / US 60 at Fisk I-55 at Perryville US 61 at Perryville
North end	IL 150 / Great River Road at the Illinois state line
Location
Country	United States
State	Missouri
Highway system
Missouri State Highway System Interstate US State Supplemental
← US 50 → Route 52

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Route 51 is one of the original 1922 state highways and ran from the Mississippi River to Advance.

Route 51A, a branch route, formerly connected Route 51 with Puxico when Route 51 ended at Advance (at Route 25). Route 51A would become part of the main highway when it was re-routed and extended.