Rupen may refer to:

• Rupen of Montfort (died 1313), Cypriot nobleman
• Rupen Sevag, real name Ruben Çilingiryan (1886–1915), Ottoman Armenian poet, prose writer and doctor, killed by Turkish authorities during the Armenian Genocide
• Rupen Zartarian (1874–1915), Ottoman Armenian writer, educator, and political activist, killed by Turkish authorities during the Armenian Genocide

• Rupen River, Gujarat, India
• Rupen River (Gir), Gujarat, India

• Reuben, a given name
• Roupen, a given name

This disambiguation page lists articles associated with the title Rupen.
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