Rupert McPherson Colmore Sr. (February 3, 1883 – July 9, 1958) was a college football player and physician. He succeeded William W. Dickey as director of the Venereal Clinics in Chattanooga.^[1] He married Margaret Bowdoin in Louisiana.^[2][3]

Colmore was born to Robert L. Colmore and Priscilla Addenbrook.^[4]

He was a member of Alpha Kappa Kappa.^[5] He was a prominent halfback and end for the Sewanee Tigers of Sewanee: The University of the South. He was captain of the 1904 team.^[6] Colmore was selected All-Southern by Nash Buckingham in 1903.^[7] Colmore was shifted from end to halfback in 1902, garnering praise for his play at both positions.^[8] George Trevor selected him as second-team end on his all-time Sewanee team.^[9]

Many of his brothers and also his son, Rupert Colmore Jr., played for Sewanee. His son is the only All-Southeastern Conference (SEC) player the school ever had.^{[citation needed]}