SCH-23390 also known as halobenzazepine, is a synthetic compound that acts as a D₁ receptor antagonist and has either minimal or negligible effects on the D₂ receptor.

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SCH-23390

Names
IUPAC name 7-chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol
Identifiers
CAS Number	87075-17-0 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:73297 N
ChEMBL	ChEMBL62 N
IUPHAR/BPS	943
PubChem CID	5018
UNII	UGT5535REQ Y
CompTox Dashboard (EPA)	DTXSID60873373 DTXSID40873376, DTXSID60873373
SMILES CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)Cl
Properties
Chemical formula	C17H18ClNO
Molar mass	287.78 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

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In a 1990 study in rats SCH-23390 offered significant protection from death in dextroamphetamine overdosage, without providing protection from death by methamphetamine overdose. The compound provided significant protection from cocaine overdose in rats only at the lowest dose tested in the measurement series. This suggested that D-amphetamine and methamphetamine at high (lethal) doses have different mechanisms of toxicity in rats.^[1]