SPE may refer to:

Look up SPE in Wiktionary, the free dictionary.

• A monomer used to make polysulfobetaines, or occasionally the resulting polymer itself
• Serum protein electrophoresis
• Solar particle event, generating very high energy protons
• Solid phase extraction, from a mixture
• Solid-phase epitaxy, from amorphous to crystalline
• The Sound Pattern of English, a 1968 book by Noam Chomsky and Morris Halle
• SpE, abbreviation for Sporadic E propagation
• Spe (planet), 14 Andromedae b
• Stanford prison experiment, in psychology
• Synchronous payload envelope, in synchronous optical networking

• Sauber Petronas Engineering, car engine manufacturer
• Societas Privata Europaea, a Europe-wide type of limited company
• Sony Pictures Entertainment, a US company
• SPE, later Luminus (company)
• Special Police Establishment, later Central Bureau of Investigation, India
• Special purpose entity, for a specific purpose

• US supervisory patent examiner
• SPE Certified, a food standard
• Société Parisienne d'Édition (S.P.É.), a French publisher

• Seasonal Player Experience, a self imposed challenge in Realm of the Mad God

• Spes (disambiguation)

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