Saginaw Trail is the collective name for a set of connected roads in Southeast and Central Michigan that runs from Detroit to Saginaw through Pontiac and Flint that was originally a tribal foot trail. To drive it today, drivers would follow:

• M-1 (Woodward Avenue) from Detroit to Birmingham;
• Old Woodward Avenue through Birmingham;
• M-1 (Woodward Avenue) from Birmingham to Pontiac;
• 
  Bus. US 24 (Woodward Avenue) into downtown Pontiac;
• Former routing of Saginaw Street through downtown within the Woodward Avenue Loop;
• 
  Bus. US 24 (Cesar E. Chavez Avenue) north of the Woodward Avenue Loop;
• US 24 (Dixie Highway) north of Pontiac to Clarkston;
• Dixie Highway, a set of various county roads that were previously US 10 from Clarkston to near Grand Blanc;
• Saginaw Road and Saginaw Street through Grand Blanc, Burton, and Flint to north of Mount Morris;
• M-54 (Saginaw Road) from north of Mount Morris near Clio to the Genesee–Saginaw County line;
• Dixie Highway and Genesee Avenue into Saginaw.