Saint Isaac may refer to:

• Isaac, son of Abraham in the Old Testament
• Saint Isaac of Dalmatia (4th-century–383)
• Saint Isaac of Monteluco, also called St. Isaac of Spoleto (died c. 550)
• Saint Isaac Jogues (1607–1646)
• Saint Isaac of Dafra
• Saint Isaac of Armenia (338–439)
• Saint Isaac of Nineveh (613–c. 700)

• Saint Isaac's Cathedral, in Saint Petersburg, Russia
• Saint Isaac's Square, in Saint Petersburg, Russia
• Saint Isaac's Bridge, the first bridge across Neva river in St.Petersburg, Russia

This disambiguation page lists articles associated with the title Saint Isaac.
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