Samos Prefecture (Greek: Νομός Σάμου) was a prefecture in Greece, consisting of the islands of Samos, Ikaria and the smaller islands of Fournoi Korseon. In 2011 the prefecture was abolished and the territory is now covered by the regional units of Samos and Ikaria. Its capital was the town of Vathy, on Samos.

The provinces were:

• Samos Province - Samos
• Ikaria Province - Agios Kirykos

• The Eupalinian aqueduct
• List of settlements in Samos
• List of settlements in the Ikaria regional unit