Samuel Lawrence may refer to:

• Samuel Lawrence (Canadian politician) (1879–1959), Canadian politician
• Samuel Lawrence (revolutionary) (1754–1827), war officer, founder of Lawrence Academy at Groton
• Samuel Lawrence (congressman) (1773–1837), U.S. Representative from New York
• Samuel T. Lawrence (1786–1847), early associate of Joseph Smith, the founder of the Latter-day Saint movement
• Samuel Hill Lawrence (1831–1868), Irish Victoria Cross recipient
• Samuel Laurence (1812–1884), British portrait painter, also spelt as Lawrence
• Samuel C. Lawrence (1822–1911), Massachusetts politician