Sanabria (Spanish pronunciation: [saˈnaβɾja], A Seabra in the Galician language, Senabria in Leonese language) is a comarca in the northwest of the province of Zamora, western Spain. It borders Portugal to the south, Orense to the west and León to the north. It belongs to the Autonomous Region of Castilla y León.

The Sierra de la Cabrera Baja forms a natural boundary with Leon Province in the north, Sierra Segundera with Galicia in the west, and Sierra de la Culebra and Sierra de la Gamoneda with the Bragança District of Portugal in the south and southwest. The comarcas of La Carballeda and Tierra del Pan are to the east. The most famous place in the comarca is the Sanabria Lake (Lago de Sanabria), the biggest glacial lake in the Iberian Peninsula, with a surface of 368 hectares (910 acres) which is now within the limits of the Sanabria Lake Natural Park. The lake was declared a Natural Park in 1978. The capital of the comarca is Puebla de Sanabria.

The Sanabria comarca is one of the few areas of Western Europe with a sizeable population of wild wolves, which live in the Sierra de la Culebra mountain range.

Sanabria is divided in 15 municipalities, which in turn include several districts or towns, of which some belong to the nearby region of La Carballeda. In the next table municipalities are listed, showing the area of each municipality in square kilometers, population according to the last INE census and the towns which are included on every municipality:

• Sierra de la Cabrera
• Peña Trevinca
• Moncalvo
• Galende