Santa Croce is Italian for 'Holy Cross' and may refer to:

• Santa Croce (Venice), one of the six sestieri (districts) of Venice, Italy.
• The Pontifical University of the Holy Cross (Italian: Pontificia Università della Santa Croce) in Rome, Italy.
• Many churches, including:
  • Santa Croce, Florence, built 1294–1385 and the burial place of several notable Italians
  • Santa Croce della Foce, Gubbio, Umbria, built in the 13th century
  • Basilica di Santa Croce (Lecce), built 1549–1646
  • Santa Croce, Parma, built 1222–1666
  • Santa Croce, Padua, built 1737–1749
  • Santa Croce in Fossabanda, Pisa, built 1325–19th century
  • Santa Croce e San Bonaventura alla Pilotta, Rome, built 1625–19th century
  • Santa Croce in Gerusalemme, Rome, consecrated around 325
  • Santa Croce alla Lungara, Rome, consecrated 1619
  • Santa Croce degli Armeni, Venice, built 13th century, consecrated 1688
  • Santa Croce in Via Flaminia, Rome, built 1913, consecrated 1981

• House of Santacroce, a noble Roman family. To this belongs among others:
  • Prospero Santacroce, 16th-century cardinal
• Fabiano Santacroce (born 1986), Italian-Brazilian football player
• Isabella Santacroce (born 1970), Italian novelist
• Girolamo Santacroce, a 16th-century Italian sculptor and painter

• Santa Croce sull'Arno, town in Tuscany
• Santa Croce Camerina, town in Sicily

• Santa Cruz (disambiguation)
• Sainte-Croix (disambiguation)
• Holy Cross (disambiguation)

This disambiguation page lists articles associated with the title Santa Croce.
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