Santa Maria Island (Spanish: Isla Santa María; Portuguese: Ilha de Santa Maria) typically refers to one of the islands in Portugal's Azores Archipelago in the North Atlantic Ocean.

It may also refer to:

• Santa María Island, Chile, in the Bío Bío Region of Chile
• Santa Maria Island, a former name of Gaua in the Pacific
• Santa Maria Island, a former name of Floreana Island in the Galápagos Archipelago, Ecuador

• Santa Maria (disambiguation)

This disambiguation page lists articles associated with the title Santa Maria Island.
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