Scipio Africanus was a Roman general who defeated his Carthaginian counterpart Hannibal.

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The name may also refer to:

• Scipio Aemilianus (Scipio Africanus Aemilianus) (185-129 BC), adoptive grandson of the original Scipio Africanus
• George Africanus (George John Scipio Africanus, 1763–1834), West African slave who became an entrepreneur in England.
• Scipio Africanus (slave) (1702–1720), West African British slave.
• Scipio Africanus Jones (1863–1943), African American educator, jurist, and politician.

• Italian cruiser Scipione Africano, an Italian warship of World War II

• All pages with titles containing Scipio Africanus
• Publius Cornelius Scipio (disambiguation)

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