The Second Magdalena massacre was an attack by Apaches against the Spanish mission village of Magdalena de Kino, in northern Mexico. The attack occurred in mid-November 1776. Most or all of Magdalena de Kino's inhabitants were killed.

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It was the second massacre in the town. In November 1757, Seri natives attacked and killed thirty-one civilians. Captain Francisco Ignacio de Trespalacios discovered the massacred colonists during a campaign from Presidio Santa Cruz de Terrenate with eighty-three cavalry men. Ignacoi replaced the fallen commander, Francisco Tovar, after the First Battle of Terrenate. The Spanish Army estimated that around forty Apaches had looted the settlement, murdered the inhabitants and burned the church.

• Capture of Tucson (1846)
• Capture of Tucson (1862)
• American Indian Wars
• Apache Wars
• Navajo Wars

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• Cooper, Evelyn S. (1995). The Buehman Studio: Tucson in Focus. Arizona Historical Society. ISBN 978-0-910037-35-8.
• Dobyns, Henry F. (1976). Spanish colonial Tucson: a demographic history. Tucson, Ariz: University of Arizona press. ISBN 978-0-8165-0546-3.
• Drachman, Roy P. (1999). From Cowtown to Desert Metropolis: Ninety Years of Arizona Memories. Whitewing Press. ISBN 978-1-888965-02-5.