The Secretary of State for Foreign and Political Affairs (Italian: Segretario di Stato per gli Affari Esteri e Politici) is the minister for foreign affairs of San Marino.

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Together with the Secretary for Interior and the Secretary for Finance, this officer is one of the three members of the executive Congress of State directly appointed by the Grand and General Council, the parliament of the republic. Due to the absence of the office of Prime Minister in the constitutional structure of San Marino, the Secretary for Foreign Affairs is traditionally regarded as the head of the Sammarinese government.^[1]

Between 27 December 2016 and 7 January 2020, the Secretary for Foreign Affairs was Nicola Renzi of the Adesso.sm left-wing coalition. Since 7 January 2020, the Secretary for Foreign Affairs has been Luca Beccari of the Sammarinese Christian Democratic Party.

• Domenico Fattori, 1860-1908
• Menetto Bonelli, 1908-1918
• Giuliano Gozi, 1918-1943
• Gustavo Babboni, 1943-1945
• Gino Giacomini, 1945-1957
• Federico Bigi, 1957-1972
• Giancarlo Ghironzi, 1972-1973 and 1976-1978
• Gian Luigi Berti, 1973-1976
• Giordano Bruno Reffi, 1978-1986
• Gabriele Gatti, 1986-2002
• Romeo Morri, May-June 2002
• Augusto Casali, June-December 2002
• Fiorenzo Stolfi, 2002-2003 and 2006-2008
• Fabio Berardi, 2003-2006
• Antonella Mularoni, 2008-2012
• Pasquale Valentini, 2012-2016
• Nicola Renzi, 2016-2020
• Luca Beccari, 2020-present

^[2]

• Congress of State
• Grand and General Council
• San Marino Secretary for Finance and Budget