Selenium_mustard

Bis(2-chloroethyl)selenide

Bis(2-chloroethyl)selenide

Chemical compound

Bis(2-chloroethyl)selenide is the organoselenium compound with the formula Se(CH2CH2Cl)2. As a haloalkyl derivative of selenium, it is an analogue of bis(2-chloroethyl)sulfide, the prototypical sulfur mustard used in chemical warfare. Bis(2-chloroethyl)selenide has not been used as a chemical warfare agent, however it is still a potent alkylating agent and has potential in chemotherapy.[1][2][3][4][5]

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See also

References

  1. [1]
    Kang SI, Spears CP (April 1987). "Linear free energy relationships and cytotoxicities of para-substituted 2-haloethyl aryl selenides and bis(2-chloroethyl) selenides". Journal of Medicinal Chemistry. 30 (4): 597–602. doi:10.1021/jm00387a003. PMID 3560155.
  2. [2]
    Kang SI, Spears CP (June 1990). "Phenyl selenones: alkyl transfer by selenium-carbon bond cleavage". Journal of Medicinal Chemistry. 33 (6): 1544–7. doi:10.1021/jm00168a003. PMID 2342050.
  3. [3]
    Kang SI, Spears CP (January 1990). "Structure-activity studies on organoselenium alkylating agents". Journal of Pharmaceutical Sciences. 79 (1): 57–62. doi:10.1002/jps.2600790114. PMID 2313578.
  4. [4]
    Hu X, Tian Z, Chen Y, Lu X (2000). "One-Pot Two-Step Approach to Selenides. Phase-Transfer Catalyzed Synthesis of ω-Hydroxyalkyl Selenides". Synthetic Communications. 30 (3): 523–529. doi:10.1080/00397910008087348. S2CID 94951635.
  5. [5]
    Potapov VA, Kurkutov EO, Musalov MV, Amosova SV (February 2014). "Synthesis of bis(2-haloethyl) selenides by reaction of selenium dihalides with ethylene". Russian Journal of Organic Chemistry. 50 (2): 291–292. doi:10.1134/S1070428014020250. S2CID 97109063.
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