Lazarus W. Powell (1812–1867) was a U.S. Senator from Kentucky from 1859 to 1865. Senator Powell may also refer to:

• Beverly Powell (born 1951), Texas State Senate
• Clifford Ross Powell (1893–1973), New Jersey State Senate
• E. Henry Powell (1839–1911), Vermont State Senate
• Eric Powell (politician) (born 1966), Mississippi State Senate
• Jeremiah Powell (fl. 1780s), Massachusetts State Senate
• Larry Powell (Kansas politician) (born 1939), Kansas State Senate
• Max L. Powell (1869–1941), Vermont State Senate
• Walter E. Powell (1931–2020), Ohio State Senate

• John Hare Powel (1786–1856), Pennsylvania

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