Setlutlu, or Masekeletu, was the spouse of Sebetwane — a chief of the Kololo people.

Her brother-in-law was King Mbololo.

Sebetwane originally awarded Setlutlu to Lechae, one of his young commanders, to serve as his wife. Later, she married Sebetwane. They had a son, Sekeletu, who later became a ruler himself.

David Livingstone met the queen at Naliele. She had much influence over the commanders that Sibituane left. Setlutlu was a grandmother of Princes Litali and Sesane.

• Makololo interregnum and the legacy of David Livingstone (PDF)