Seychelles competed in the Olympic Games for the first time at the 1980 Summer Olympics in Moscow, USSR.

Nine athletes represented Seychelles in 1980.

Men's 100 metres

• Marc Larose

• Heat — 10.62 (→ did not advance)

Men's 200 metres

• Casimir Pereira

• Heat — 21.29 (→ next round)

Men's 400 metres

• Régis Tranquille

• Heat — 49.34 (→ did not advance)

Men's Marathon

• Albert Marie

• Final — did not finish (→ no ranking)

Men's 110 m Hurdles

• Antonio Gopal

• Heat — 16.36 (→ did not advance)

Men's 3,000 m Steeplechase

• Albert Marie

• Heat — 9:19.7 (→ did not advance)

Men's 4 × 100 metres Relay

• Marc La Rose, Regis Tranquille, Casimir Pereira and Vincent Confait

• Heat — 41.71 (→ did not advance)

Men's 4 × 400 metres Relay

• Vincent Confait, Regis Tranquille, Marc La Rose and Casimir Pereira

• Heat — 3:19.2 (→ did not advance)

Men's Triple Jump

• Arthure Agathine

• Qualification — 14.21 m (→ did not advance, 20th place out of 23)

Women's 100 metres

• Bessey de Létourdie

• Heat — 13.04 (→ did not advance)

Women's 200 metres

• Bessey de Létourdie

• Heat — 26.91 (→ did not advance)

Women's 800 metres

• Margaret Morel

• Heat — 2:17.0 (→ did not advance)

Women's 1,500 metres

• Margaret Morel

• Heat — 4:37.9 (→ did not advance)

Two boxers represented Seychelles in 1980.

Men's Featherweight (57 kg)

• Ramy Zialor
  1. First Round — Bye
  2. Second Round — Lost to Leoul Nearaio (Ethiopia) on points (2-3)

Men's Welterweight (67 kg)

• Michael Pillay
  1. First Round — Defeated Ole Svendsen (Denmark) on points (4-1)
  2. Second Round — Lost to Mehmet Bogujevci (Yugoslavia) on knock-out in first round