The college's campus in Taytay is now located at E. Rodriguez Avenue, Siena Heights, Barangay San Isidro, Taytay, Rizal. The main and oldest, facility, the three-story Saint Catherine Building located at the town proper adjacent to the Saint John the Baptist Parish church, was gutted by fire in 2002 and was not rebuilt. At the new location, a four-story building was constructed. This has a number of classrooms and a large Speech Laboratory in the newly added third floor. There are also houses for freshman high school students.
The Mother Natividad Pilapil O.P. (Latin: Ordinis Praedicatorum; English: Order of Preachers) building houses kindergarten 1 and 2, grade one pupils, and faculty rooms for their teachers. It is located through Gate 1 of the campus.
The Saint Dominic De Guzman Building, named after the founder of the Dominican order, houses the junior and senior high school students, computer rooms for college and high school students, and the Cyber program. It also houses the registrar's office, guidance office, testing center, high school library, GLL office, YLL office, and Instructional Media Center.
The Saint Thomas Aquinas Building contains instructional rooms for the senior high and college students, laboratories, and college library. It can be accessed through Gates 3 and 4. The building is named after the 13th-century philosopher.
The Our Lady of the Holy Rosary Building houses the publishing office, cafeteria, clinic and chapel.
The Saint Jacques Centre de Formatione - Hotelliere et Restaurateur (Saint Jacques Center for International Hospitality Education - Hotel and Restaurant) houses the college's signature program in Hotel and Restaurant Management. It also houses senior high students in the TECH-VOC Strand, with specialization in cookery. Historically, the Parisian Dominican house was located in the parish of Saint Jacques.
The Mother Francisca Hall is an auditorium. The San Lorenzo Ruiz Hall is named for the Filipino martyred during persecution of Japanese Christians under the 17th-century Tokugawa Shogunate. The gymnasium offers student facilities, including the St. Catherine Covered Court, an Olympic-sized swimming pool, and the St. Martin Sports Complex.
The Saint Albertus Magnus building was scheduled to house college students in the 2018–2019 school year. The building is composed of 24 rooms on four floors.
