Significance, established in 2004, is a bimonthly print and digital magazine published by Oxford University Press on behalf of the Royal Statistical Society (RSS), the Statistical Society of Australia (SSA) and the American Statistical Association (ASA).^[1] It publishes articles on topics of statistical interest presented at a level suited for a general audience. Articles are reviewed by an editorial board of statistics experts drawn from the three societies.^[2] The founding editor-in-chief was Helen Joyce.^[3] The current editor is Anna Britten. Significance replaced the RSS's journal, The Statistician.^[4] The magazine also has a website.

In addition to ordinary articles in the magazine, additional "virtual issues" (collections of articles on a particular subject area) are made available online.^[5] In November 2010 the magazine launched its website.^[6] Having been launched as a quarterly magazine, Significance changed to a bimonthly frequency in 2011. In 2020, the regular column 'Dr Fisher's Casebook' was renamed 'the secret statistician', a review prompted by concern about Fisher's views on eugenics (and supported by the lack of salience of the homage to Dr Finlay's Casebook).^[7]

Members of either the RSS or the ASA receive the magazine as part of their membership.^[1] In January 2015, the RSS and ASA decided to make the magazine issues available to the public free of charge a year after their publication.^[8]