Sister2Sister or S2S are an Australian duo comprising the Muscat sisters, Christine and Sharon, who are pop singers, songwriters and television presenters. Their debut album, One (June 2000), peaked at No. 3 on the ARIA Albums Chart. It provided two top five singles, "Sister" (1999) and "What's a Girl to Do?" (2000). At the ARIA Music Awards of 2000 "Sister" won Best Independent Release. From 2001 they undertook a career as television presenters, as VJs on MTV Hits, and subsequently opened the Sister2Sister School of Singing in 2004.^[1] The sisters have performed as backing vocalists for Australian singer Delta Goodrem on her Australian tours.^[2]

The Muscat sisters, Christine (born 27 February 1981) and Sharon (born 23 August 1984 to Maltese immigrants), are the duo that make up Sister2Sister. Their career started young when they grew up in the Sydney suburb of St. Clair, where they attended Holy Spirit Primary school and later Emmaus Catholic College in nearby Erskine Park.^{[citation needed]}

Growing up in a musical family, it was during those early years that the two developed a love for music. However, they also had a knack for acting ^{[citation needed]}, which resulted in both of them television presenting and landing roles in TV commercials and soap operas.^{[citation needed]}

At the ages of 9 and 13, Christine and Sharon joined Brent Street Studios to also study dancing. Soon after joining the school, the girls were invited to join the Brent St. Kids performance troupe and began singing and dancing all over Sydney. It was through this exposure that they attracted the attention of Tina Arena who saw their performance at the Variety Club Heart Awards. Arena mentioned the girls to her now former manager/husband. He later signed them to his management company and new record label in 1997.^{[citation needed]}