2010–2012

In 2010 Mukherji directed his debut feature film, the award-winning blockbuster – Autograph (starring Prosenjit Chatterjee, Indraneil Sengupta and Nandana Sen) which was both critically acclaimed and commercially successful. The film won 41 awards and was an official selection at Abu Dhabi International Film Festival 2010, MIAAC Film Festival in New York 2010, Glasgow International Film Festival 2011 and London Indian Film Festival 2011.^[9]

In the same year he also made his acting debut on Bengali television in the Rituparno Ghosh scripted mega serial Gaaner Opare, produced by Ideas Entertainment.^[10]

His work in 2011 included a major role in Anindya Banerjee's Chaplin starring Rudranil Ghosh and his second film, Baishe Srabon starring Prosenjit Chatterjee, Parambrata Chatterjee, Raima Sen, Abir Chatterjee and Gautam Ghose, who returned to acting after a hiatus of 29 years. Baishe Srabon was recently the official selection at the Dubai International Film Festival and the closing film at the London Indian Film Festival, and had a 105-day run at the box office making it the biggest blockbuster of the year. Baishe Srabon has won 41 awards. His third feature film was Hemlock Society, a romantic satire set at the backdrop of a school which teaches aspirants how to successfully commit suicide. It featured Parambrata Chatterjee and Koel Mallick and won 21 awards.

2013–2016

Mukherji's fourth film, Mishawr Rawhoshyo, based on Kakababu with Prasenjit Chattopadhyay playing the lead character and Indraneil Sengupta playing the role of Hani Alkadi, has been declared as one of the biggest blockbusters ever and the highest earning urban mainstream film. He has acted in films like Dutta Vs Dutta, Bapi Bari Jaa and the national award-winning Shobdo. His fifth film Jaatishwar, featuring Prosenjit Chatterjee and Jisshu Sengupta, is generally considered to be the best in his career and most critically acclaimed. It is the musical bridge between two centuries of Bengali culture and a biopic cum a musical cum a reincarnation drama. At the 61st National Awards 2014, the highest film honour in India, it won 4 national awards for Music Direction, Playback Singing, Costume and Make up. This was the highest tally for a film in India this year, and the second highest ever for a Bengali film. It also swept the Mirchi Music Awards in 2015 winning 7 awards. The following year at the 62nd National Awards 2015, Chotushkone won him the Best Director and Best Original Screenplay awards, along with winning the Best Cinematography.

He also received the Young Achiever Award from Rotary International, the prestigious Shera Bangali Award from ABP Anando and the Shoilojanando Mukhopadhyay Memorial Award in 2012 for his contribution in the field of film direction. In 2013 he received the Uttam Kumar Memorial Award from the Government of West Bengal becoming the youngest director to achieve this. He has also received the oldest film award in India, the BFJA award, for remarkable contribution to Bengali Cinema in the last few years.^[11]

2017–2020

Mukherji has made his directorial debut in Bollywood with the film Begum Jaan which is a remake of his earlier Bengali film Rajkahini. Vidya Balan plays the lead role of a brothel's madam during the partition of India in 1947.^[12][13] He had two releases in 2018, Uma and Ek Je Chhilo Raja. Both featured Jisshu Sengupta and were box office superhits. The former went to 10 film festivals around the world and won 6 awards while the latter won 23 awards and went to 7 film festivals around the world including Palm Springs International Film Festival. In 2018, it was reported that Mukherji will be directing a Junglee Pictures produced yet to be titled web-series in Hindi, based on the novel of noted novelist and blogger Arnab Ray, The Mahabharata Murders. This will be his first foray into web-series direction.^[14] In 2019, he has three releases Shahjahan Regency, Vinci Da and Gumnaami, the last two being both critical and commercial successes along with being a festival favourite. Gumnaami won the Best Bengali Feature Film and Best Adapted Screenplay Awards at the 67th National Film Awards.

He has also completed another web-series, Feluda Pherot, which is based on two Feluda stories written by Satyajit Ray, Chhinomostar Obhishaap and Darjeeling Jomjomat.^{[clarification needed][15]}

2021-present

After no films in 2020 due to COVID-19, in 2021 he had 4 releases, out of which 2 were Hindi films. He directed Kakababur Protyaborton, which was based on the third film of the Kakababu franchise, it had Prosenjit Chatterjee as Kakababu, Aryann Bhowmik, Anirban Chakrabarti in the lead roles. His next release wass X=Prem. A black and white romance drama film with debutant actors, the film earned critical praise and received several awards and nominations at the Filmfare Awards Bangla^[16] and WBFJA Awards.

His next projects that year were two Bollywood films: Sherdil: The Pilibhit Saga and Shabaash Mithu. The latter was the biography of one of the most influential Indian female cricketer Mithali Raj.^[17]

In 2023, he released Dawshom Awbotaar, a neo-noir crime thriller as the 4th installment Srijit Mukherji's Cop Universe. It served as the prequel crossover of his previous films Baishe Srabon and Vinci Da. It became a huge box office success emerged as one of the highest grossing Bengali films of 2023.^[18] The film received mulltiple nomination and awards at the Filmfare Awards Bangla and WBFJA Awards.^[19]

His first release in 2024 was the fantasy romantic comedy film Oti Uttam. For the first time ever in Indian Cinema, veteran actor Uttam Kumar appeared in the movie through Visual effects by using his scenes from his 56 existing old movies.^[20]

As director

Web series

As lyricist and actor

Also as an Actor(Cameo Roles) in all the films he directed