St Patrick's College was an independent Catholic school in Melbourne, Victoria from 1854 until 1968. It was the second independent school and the first Catholic secondary school in Victoria founded with a government grant of £2,500.^[1] In 1865, following financial difficulties, it was transferred to the care of the Society of Jesus (Jesuits).^[2] The school became immediately important to the intellectual and spiritual life of the Catholic community of Victoria and remained so for its existence.^[3] The College was a member of the Associated Catholic Colleges from 1928–1948.

The school was shut down at the end of 1968 in order to provide space for a new Catholic diocesan chancery.^[4] After significant public opposition the buildings were demolished in 1970.^[3] Over 5000 students attended the school between its foundation and closure.^[5] The St Patrick's Old Collegians' Association continues to exist.^[6]

• Keith Brennan (1915–1985) – diplomat^[7]
• Vincent Buckley (1925–1988) – poet, essayist
• Frank Costigan (1931–2009) – lawyer
• Michael Costigan (1931– ) – writer and public servant
• Henry Doyle (1859–1929) – politician
• John Nash (1857–1925) – politician
• Jack O'Hagan (1898–1987) – singer-songwriter and radio personality
• Richard Michael "Dick" Pirrie (1920–1944) – VFL Footballer, Naval Officer, died in the D-Day Landings of 6 June 1944
• Joseph Santamaria – judge of the Court of Appeal, Supreme Court of Victoria
• Thomas Fidelis Hawkins, (1940–1946) – Commonwealth Bank of Australia

• Rev. Thomas Cahill SJ (1874–1878)
• Rev. William Lockington SJ (1916–1923)