In pathology, salt-and-pepper chromatin, also salt-and-pepper nuclei and stippled chromatin, refers to cell nuclei that demonstrate granular chromatin (on light microscopy).^[1]

Salt-and-pepper chromatin is typically seen in endocrine tumours such as medullary thyroid carcinoma, neuroendocrine tumours^[2] and pheochromocytoma.^[3]

• Neuroendocrine tumour of the lung with salt-and-pepper chromatin. H&E stain.
• Neuroendocrine tumour of the small intestine with salt-and-pepper chromatin. H&E stain.
• A pheochromocytoma showing finely granular chromatin. H&E stain.
• Salt-and-pepper chromatin (pheochromocytoma). H&E stain.