Sulazepam

Sulazepam

Sulazepam

Chemical compound

Sulazepam is a benzodiazepine derivative. It is the thioamide derivative of diazepam. It is metabolised into diazepam, desmethyldiazepam and oxydiazepam[citation needed]. It has sedative, muscle relaxant, hypnotic, anticonvulsant and anxiolytic properties like those of other benzodiazepines.[1][2] It was never marketed.

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Synthesis

Sulazepam synthesis:[3] U.S. patent 3,141,890

Treatment of diazepam with phosphorus pentasulfide produces the corresponding thionamide, sulazepam.

See also

References

  1. [1]
    "sulazepam". psychotropics.dk. 2003. Retrieved 29 December 2008.
  2. [2]
    Golovenko NI, Zin'kovskii VG (September 1976). "[Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice]" [Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice]. Biulleten' Eksperimental'noi Biologii I Meditsiny (in Russian). 82 (9): 1078–81. PMID 11012.
  3. [3]
    Archer GA, Sternbach LH (1964). "Quinazolines and 1,4-Benzodiazepines. XVI. Synthesis and Transformations of 5-Phenyl-1,4-benzodiazepine-2-thiones". The Journal of Organic Chemistry. 29: 231. doi:10.1021/jo01024a511.
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