TCA may refer to:

Look up tca in Wiktionary, the free dictionary.

• Toxin complex a, an insecticidal toxin complex produced by Photorhabdus luminescens bacteria
• Tricarboxylic acid cycle, an alternate name for the citric acid cycle pathway in cellular metabolism
• Trichloroacetic acid, chemical used to precipitate protein in serum
• 2,4,6-Trichloroanisole, cause of cork taint in wine
• Tricyclic antidepressant, a class of medications
• TCA, a codon for the amino acid serine

• Taiwanese Cultural Association
• Tekeyan Armenian Cultural Association, a network of Armenian cultural organisations
• Television Critics Association
• The Canadian Amateur, radio amateur magazine
• Tribune Content Agency, a syndication company owned by Tribune Publishing
• Triple Crown of Acting is a term used in the American entertainment industry to describe actors who have won a competitive Academy Award, Emmy Award, and Tony Award in the acting categories
• Twentieth Century Animation, the animation division of 20th Century Studios

• Transaction cost analysis
• Total cost of acquisition
• True cost accounting

• The Classical Academy (Colorado), Colorado Springs, US
• Trinity Christian Academy (Deltona, Florida), US
• Trinity Christian Academy (Jackson, Tennessee), US

• Taipei Computer Association
• The Consulting Association
• Total Community Action
• Trans-Canada Air Lines, predecessor to Air Canada
• Train Collectors Association
• Transportes Carga Aérea, a defunct Brazilian airline

• Taiwan Constitution Association, a political party in Taiwan
• EU–UK Trade and Cooperation Agreement, between the UK and the EU (2020)
• The Competition Authority (Ireland) (2002–2014)

• Terminal control area, a volume of controlled airspace
• Topology change acknowledgement, a message in the 802.1D Spanning Tree Protocol (STP)
• Transportation Corridor Agencies, a toll road authority in Orange County, California
• Traumatic cardiac arrest, due to trauma
• Tennant Creek Airport, IATA airport code "TCA"
• Turks and Caicos Islands, country code

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