TGIF may refer to:

• Thank God It's Friday (disambiguation), a common expression.

Look up TGIF in Wiktionary, the free dictionary.

• TGIF (TV programming block), a former two-hour programming block on the American television network ABC
• "Last Friday Night (T.G.I.F.)", a 2011 single by Katy Perry
• "T.G.I.F. (Thank God I'm Fresh)", a song from the bonus tracks of Kid Cudi's album Man on the Moon: The End of Day
• "T.G.I.F.", a song from the Lonestar album Let's Be Us Again (2004)
• "TGIF", a song from the K.Flay album Inside Voices / Outside Voices (2022)
• "TGIF", a song from the Le Tigre album Feminist Sweepstakes

• Tgif (program), an interactive 2-D drawing tool under X11 for Unix and the file format it uses, .tgif
• Tactical Ground Intercept Facility, a US Military Intelligence collection platform
• Transforming growth interacting factor
  • TGIF1, a protein that in humans is encoded by the TGIF1 gene
  • TGIF2, a protein that in humans is encoded by the TGIF2 gene

• T.G.I. Friday's, an American restaurant chain

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