TNKS2

Tankyrase 2

Tankyrase 2

Protein-coding gene in the species Homo sapiens

Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.[5]

Quick Facts TNKS2, Available structures ...


Interactions

TNKS2 has been shown to interact with GRB14,[6] TERF1[7][8][9] and Cystinyl aminopeptidase.[8][9][10]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000107854 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000024811 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2".
  6. [6]
    Lyons RJ, Deane R, Lynch D K, Ye Z S, Sanderson G M, Eyre H J, Sutherland G R, Daly R J (May 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. 276 (20). United States: 17172–80. doi:10.1074/jbc.M009756200. ISSN 0021-9258. PMID 11278563.
  7. [7]
    Cook BD, Dynek Jasmin N, Chang William, Shostak Grigoriy, Smith Susan (January 2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres". Mol. Cell. Biol. 22 (1). United States: 332–42. doi:10.1128/MCB.22.1.332-342.2002. ISSN 0270-7306. PMC 134233. PMID 11739745.
  8. [8]
    Chi NW, Lodish H F (Dec 2000). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles". J. Biol. Chem. 275 (49). UNITED STATES: 38437–44. doi:10.1074/jbc.M007635200. ISSN 0021-9258. PMID 10988299.
  9. [9]
    Sbodio JI, Lodish Harvey F, Chi Nai-Wen (February 2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. 361 (Pt 3). England: 451–9. doi:10.1042/0264-6021:3610451. ISSN 0264-6021. PMC 1222327. PMID 11802774.
  10. [10]
    Sbodio JI, Chi Nai-Wen (August 2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. 277 (35). United States: 31887–92. doi:10.1074/jbc.M203916200. ISSN 0021-9258. PMID 12080061.

Further reading


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