TRNA_(cytidine56-2'-O)-methyltransferase

TRNA (cytidine56-2'-O)-methyltransferase

TRNA (cytidine56-2'-O)-methyltransferase

Enzyme

tRNA (cytidine56-2'-O)-methyltransferase (EC 2.1.1.206, aTrm56, tRNA ribose 2'-O-methyltransferase aTrm56, PAB1040 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine56-2'-O)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytidine56 in tRNA S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA
Quick Facts Identifiers, EC no. ...

The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2'-O-ribose methylation of cytidine at position 56 in tRNA transcripts.

References

  1. [1]
    Renalier MH, Joseph N, Gaspin C, Thebault P, Mougin A (July 2005). "The Cm56 tRNA modification in archaea is catalyzed either by a specific 2'-O-methylase, or a C/D sRNP". RNA. 11 (7): 1051–63. doi:10.1261/rna.2110805. PMC 1370790. PMID 15987815.
  2. [2]
    Kuratani M, Bessho Y, Nishimoto M, Grosjean H, Yokoyama S (January 2008). "Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA". Journal of Molecular Biology. 375 (4): 1064–75. doi:10.1016/j.jmb.2007.11.023. PMID 18068186.


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