TRNA_(cytosine-5-)-methyltransferase

tRNA (cytosine-5-)-methyltransferase

tRNA (cytosine-5-)-methyltransferase

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In enzymology, a tRNA (cytosine-5-)-methyltransferase (EC 2.1.1.29) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + tRNA S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine
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Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing 5-methylcytosine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase. Other names in common use include transfer ribonucleate cytosine 5-methyltransferase, and transfer RNA cytosine 5-methyltransferase.

References

    • Hurwitz J, Gold M, Anders M (1964). "The Enzymatic Methylation of Ribonucleic Acid and Deoxyribonucleic Acid. 3. Purification of Soluble Ribonucleic Acid-Methylating Enzymes". J. Biol. Chem. 239: 3462–3473. PMID 14245404.
    • Bjork GR, Svensson I (1969). "Studies on microbial RNA. Fractionation of tRNA methylases from Saccharomyces cerevisiae". Eur. J. Biochem. 9 (2): 207–215. doi:10.1111/j.1432-1033.1969.tb00596.x. PMID 4896260.
    • Keith JM, Winters EM, Moss B (1980). "Purification and characterization of a HeLa cell transfer RNA(cytosine-5-)-methyltransferase". J. Biol. Chem. 255 (10): 4636–4644. PMID 7372600.


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