After being on the run for six months, Richard Kimble finds himself in Tucson, Arizona under the name of James Lincoln. He has checked himself into a hotel and has found a job as a bartender at the Branding Iron. There he meets Monica Welles, the piano player with a young son who has escaped her physically abusive, estranged husband Ed Wells. After Kimble falls for her, Ed wants him out of town or dead.

Guest Stars: Vera Miles as Monica Welles, Brian Keith as Ed Welles, Donald Losby as Mark Welles, Harry Townes as Sgt. Burden, Dabbs Greer as Detective Fairfield, and Paul Birch as Captain Carpenter.
• Barry Morse appears in this episode.

In West Virginia, Kimble arrives at a local coal mining town where he is roughed up by the redneck locals and then chased by a sheriff's posse. Hiding in the mountains, Kimble meets Cassie, a young woman living in a remote cabin with her grandmother. Cassie tells Kimble she will get him to safety because she knows the area, but what she is really wanting is to keep him around for her own selfish reasons. Meanwhile, Gerard flies to West Virginia after learning from the sheriff that Kimble has been spotted in the area and teams up with the posse to try to find him.

Guest Stars: Sandy Dennis as Cassie, Bruce Dern as Deputy Martin, Frank Sutton as Del Jackson, Ruth White as Grams, R.G. Armstrong as Sheriff Bradley, and Paul Birch as Captain Carpenter.

• Barry Morse appears in this two-part episode.
Guest Stars: Susan Oliver as Karen, Robert Duvall as Eric, Will Kuluva as Lars Christian (Part 1), and Paul Birch as Captain Carpenter (Part 1).

Kimble finds work as a cut man for boxer, Joe Smith. Joe confides in Kimble that he wanted to be a doctor, but he chose boxing because he felt that being a black man would be an obstacle in the world of medicine. When Kimble discovers that Joe is suffering from memory loss, both Kimble and Joe's wife, Laura, fear that Joe might have brain damage from his boxing and that if he continues to box, it will kill him. Meanwhile, a police detective named Henry Stone goes undercover as a sports writer to investigate Joe's manager, Lou, for possible mob ties. When a disgruntled boxing worker tips off Stone that he suspects that someone might be wanting Joe to throw his next fight, the detective investigates Kimble.

Kimble, who is now working as a farm laborer, and a group of farm workers are surrounded in the hills by a huge brush fire and he must reveal that he is a doctor in order to deliver a pregnant, illegal immigrant's baby. When the news of Kimble's charitable act is reported to the press, Gerard gets wind of it and believes that Kimble is the unnamed doctor.

Kimble is thrown in jail in a rural Kentucky town after a minor traffic accident by a sheriff who hates outsiders and his fingerprints are put out over the wire. Before Gerard arrives, Kimble breaks out of the jail with his cellmate, a friendly, overweight young man named Davey "Fatso" Lambert. Hiding out at the Lambert ranch, Kimble sees that Davey's father and brother, Frank, treat the slow-witted Davey badly and blame him for a barn fire years earlier. Kimble tries to prove Davey's innocence as Gerard flies out to Kentucky after learning of Kimble's arrest.

Guest Stars: Jack Weston as Davey Lambert, Burt Brinckerhoff as Frank Lambert, Glenda Farrell as Maggie Lambert, Vaughn Taylor as Sheriff Crowley, Henry Beckman as Brown, Paul Langton as Sheriff, Garry Walberg as the Mechanic, King Calder as David Lambert, and Paul Birch as Captain Carpenter.

Kimble has a recurring nightmare that he is on a city street, is spotted by Gerard, and then runs, only to find himself cornered in an alley where Gerard shoots him dead. He awakens from the latest encounter with this nightmare when a school bus crashes and erupts in flames outside of a small New England town of Northoak. Kimble rescues children and the injured driver before an explosion knocks him unconscious. Al Springer, the local sheriff, and his wife Wilma, help the stranger recover, but when their son innocently photographs the injured Kimble for the local paper, the picture makes national news, and brings Gerard to Northoak. Sheriff Springer must thus arrest Kimble, but Gerard cannot take him back to Stafford until extradition papers are prepared, and in the process the townspeople go to the jail to say goodbye to Kimble, giving him an unexpected opportunity to escape.

Guest Stars: Nancy Wickwire as Wilma Springer, Frank Overton as Al Springer, Paul Carr (actor) Paul Carr as Deputy Ernie, Scott Lane as Larry Springer, Paul Birch as Captain Carpenter, Harry Hickox as Charley, Doreen Lang as Anna, Ian Wolfe as Dr. Babcock, Bobs Watson as Milt Plummer, Charles Herbert as Cal, Bill McLean as Barney the bus driver, Barbara Pepper as Matty, Sue Randall as Jen, and Victor Paul and Laura Gile as townspeople.

Working as a stock clerk in a department store, Kimble witnesses his boss, Martin Rowland, accidentally kill a business associate in the parking lot after hours. When Kimble learns that an elderly local vagrant found near the crime scene is the prime suspect, Kimble anonymously phones Rowland to get him to confess to the murder, but Rowland and his wife, Ginny, thinking that the caller is blackmailing them, hires the store detective, Angstrom, to find the person "blackmailing" Rowland.

Guest Stars: Leslie Nielsen as Martin Rowland, Diana Van der Vlis as Ginny Rowland, and Edward Binns as Angstrom.

Working at a remote construction site in Utah, Kimble convinces his supervisor, Buck Harmon, to hire Jamie, an intellectually disabled, but physically strong young man to help out. Jamie becomes an easy target for the taunts of the other work crew members, so Kimble becomes Jamie's protector. When Jamie is accused of sexually assaulting Buck's wife, who has been teaching Jamie how to read, he becomes frightened and runs away. The crew foreman, Dan Pike, convinces Buck to organize a posse to hunt down Jamie and kill him. Kimble has to try to save him from being lynched and find out who the unknown attacker is.

In San Francisco, Kimble is nearly run over by a car driven by Ruth Norton, a beautiful young flight attendant distraught over discovering that the man she has been dating for the past four months is married with two children. While recuperating in the hospital, a delirious Kimble flashes back to the months leading up to the night of Helen Kimble's murder and Kimble first seeing the one-armed man Fred Johnson fleeing from his house, followed by Kimble's trial, sentence, and escape from the train wreck. Ruth, who has been keeping a vigil at Kimble's bedside, hears him mutter Helen's name. Aware of his real identity, Ruth takes Kimble, who is going by George Browning, to her apartment to recover. In turn, Kimble helps her realize the married man she's dating, Paul, is not right for her.

Guest Stars: Pamela Tiffin as Ruth Norton, Diane Brewster as Helen Kimble, Ed Nelson as Paul Clemments, and Jerry Paris as Jim Prestwick.

Kimble returns to his hometown of Stafford, Indiana, after learning that his father, John, has suffered a heart attack. John has donated his medical library to the University of Wisconsin and is in the process of selling the family home. While Kimble hides out at the home of his loving sister, Donna, and her sympathetic husband, Leonard, he blames himself for their father's condition. Kimble is further troubled by his younger brother, Ray, who believes Kimble is guilty and thinks he's to blame for ruining his life, since people see Ray as "the brother of a killer." Meanwhile, Gerard arrives in town to search for Kimble and focuses on Donna and Leonard, who try to shake off the relentless detective long enough for Kimble to get out of town before he gets caught. First, though, Richard must convince Ray of his innocence - even to the point of turning himself in.

Guest Stars: Robert Keith as John Kimble, Andrew Prine as Ray Kimble, Jacqueline Scott as Donna Kimble Taft, James Sikking as Leonard Taft, Paul Birch as Captain Carpenter, Bill Mumy as David Taft, and Clint Howard as Billy Taft.

Kimble is working as the caretaker at a spacious ranch in Connecticut which is owned by newspaper heiress Ann Guthrie (guest star Peggy McCay), who lives with her husband Harlan (guest star Robert Webber) and her sister Carol (guest star Pippa Scott). Ann and Carol's late father founded the Westborne Clarion, the newspaper that Harlan currently runs. Although Ann is the sole benefactor of her father's estate, she believes Carol is entitled to part of the fortune. Unfortunately, Ann is unaware that the greedy Carol is having an affair with Harlan and they plot to murder Ann and make it look like an accident so that they can claim everything. When Kimble suspects Carol and Harlan's plan and informs Ann, the skeptic heiress refuses to believe Kimble. Once Harlan and Carol figure out that Kimble knows, the crafty couple plot to frame him for Ann's murder.

While working as a hotel lifeguard in Reno, Nevada, Kimble is caught in the middle of a feud between the hotel owner, Dan Polichek, and his spoiled and rambunctious teenage daughter Christine. Christine believes her father drove away her mother, who committed suicide years ago, and she sets out to disgrace her father by provoking bar fights and humiliating herself, but goes too far when she pretends to be having an affair with the reluctant Kimble.

Guest Stars: Telly Savalas as Dan Polichek and Joanna Frank as Christine Polichek.

In Chicago, Kimble contacts Mike Decker, a newspaper columnist who defended Kimble during his trial, unaware the newspaper man is under pressure from his boss to either find the killer or to turn Kimble over to the police to get a big story. Kimble and Decker organize a city-wide search for the one-armed man, but things get complicated with the arrival of Decker's alcoholic wife, Paula, who gets nervous of Kimble's presence and falls off the wagon. Meanwhile, Gerard learns about Decker's search for a one-armed man and decides to use the writer to set a trap for Kimble.
Guest Stars: Pat Hingle as Mike Decker, and Nan Martin as Paula Decker.

• Barry Morse appears in this episode.

Kimble works as a kennel man for Max Bodin, a breeder of prize-winning Irish Setter show dogs and who is currently putting his kennel up for sale. Max's son, Johnny, and Johnny's wife, Cora, discover that one of the dogs has developed hip dysplasia, which means that all of the dogs in the bloodline will likely inherit the condition and be worthless as show dogs, but they keep the news from Max because they plot to live off the sale. When Kimble stumbles onto their plan, they decide to have him investigated.

Herbie Grant, a second rate hoodlum, is shot in the leg while trying to rob a liquor store where Kimble works. Herbie later takes Kimble hostage where Herbie claims that although he tried to rob the store, he is innocent of two other liquor store robberies in the other towns. Kimble agrees to help clear Herbie, so he lets Kimble go. Kimble is summoned to the local police station to give his statement on the robbery, where he is recognized by Herbie's sister, Lorna, who works at the local post office. She threatens to turn Kimble in unless he turns over her brother, whom she believes to be guilty of all robberies. At a local motel where Herbie is staying he is recognized by a maid who calls the police and they arrest him. Thinking that Kimble double crossed him, Herbie reports Kimble to the police.

While working as a health club masseur, Kimble is recognized by Sheriff Bray, a local lawman with political aspirations. Kimble manages to escape with the help of a co-worker, Steve Edson. After revealing his secret to Steve, Kimble learns that Steve is a fugitive of his conscience because five months earlier, Steve was tried and acquitted for the murder of his girlfriend Linda's abusive brother—a murder that Steve actually committed. Steve cannot live with the guilt over having gotten away with it. Kimble reluctantly lets Steve travel with him, but Steve begins leaving behind clues that soon put Sheriff Bray back on their trail, including contacting Linda for help, and letting her vengeful other brother, Joey, track them down.

While working as a roller rink supervisor, Kimble is recognized by the horribly scarred Joe Hallop, a former Korean War veteran who blames Kimble for his condition. Apparently back in the Korean War, Kimble was nearly killed in an enemy grenade explosion in which Joe shielded Kimble and got his face disfigured in the process. Knocked out, Kimble never knew who saved his life. Joe plots to lure Kimble into a remote area to either disfigure him or to kill him by using his one of his war mementoes: a live grenade.

While working as a warehouse worker, Kimble is recognized by the Greek-born owner, Gus Priamos. Gus tells Kimble that he is dying from cancer and has only six months to live and hopes he can aid him with a scheme to make it look that Kimble has fled the country to Greece, but when Gus' jealous girlfriend, Sophie, learns Kimble's identity through a magazine article, she contacts Gerard and gives him a heads-up on Kimble and Gus' plan.

While working as a migrant worker in New Mexico, Kimble becomes an unwilling party to the kidnapping of a young boy who is the son of his landowner boss. The boy, Jimmie, has been abducted by Ralph Simmons, a disgruntled former pro-football player, along with his wife Helen, and his cousin Dave, who want a ransom of $200,000. When Kimble discovers that Jimmie is a haemophiliac and that Ralph has bruised him during the abduction, Kimble must find a way to get the boy away from the kidnappers and to a hospital or Jimmie will soon die from internal bleeding.

While working as a research technician for the wealthy Allan Pruitt, Kimble gets involved in the business of Allan's teenage daughter, Janice, who returns home after spending a year in a mental hospital recovering from a nervous breakdown after witnessing a young boy under her care getting mauled and killed by two vicious stray dogs. Allan's new wife, Dorina, does not take a liking to Janice and plots to drive her insane by hiring a neighbour to make his pet dogs bark in the nearby woods and convince Janice that the dogs are alive, even though they were captured and put to sleep by the local dog catcher. When Kimble claims that he has heard the dogs barking, Dorina asks the local sheriff to investigate Kimble to find any dirt on him.

A discarded photograph, with Kimble in the background, leads Gerard to Chicago, where he assembles a team of detectives to trap Kimble within an eight-block radius of the city. With Kimble wandering from place to place and being recognized by whomever he comes into contact with, he flees from both policemen and local citizens, finding refuge in a small house, which is the home of two bickering middle-aged men who have long argued over the Fugitive's innocence.