The Theaterhochschule Leipzig was a theatre school in Leipzig, Saxony, Germany, which existed from 1953 to 1992. The official name was Theaterhochschule "Hans Otto" Leipzig.

The Theaterhochschule Leipzig was founded on 1 November 1953 as a merger of two institutions, the Deutsches Theater-Institut [de] in Weimar and the Theaterschule Leipzig. From the late 1960s, Bertolt Brecht was a teacher. In 1967 it was named after the actor Hans Otto whom the Nazis had murdered in 1933. The Hochschule was located at the Villa Sieskind in the Musikviertel [de] and buildings in the neighbourhood.

The institution was dissolved per the Sächsisches Hochschulstrukturgesetz on 10 April 1992. The acting department became a faculty of the Hochschule für Musik und Theater "Felix Mendelssohn Bartholdy", while theatre studies formed a new institute of the Leipzig University.

• Eberhard Esche (1933–2006), actor
• Jürgen Holtz (1932–2020), actor on stage and in film, artist and author
• Julia Jäger (born 1970), actress
• Sonja Kehler (1933–2016), actress and chanson singer
• Volkmar Kleinert (born 1938), actor, recitator
• Harry Kupfer (1935–2019), opera director, recipient of the National Prize of the GDR
• Ute Lubosch (born 1953), actress, stage director
• Hans-Peter Minetti (1926–2006), actor
• Ulrich Mühe (1953–2007), actor in film and theatre, Academy Award for Best Foreign Language Film
• Günther Rücker (1924–2008), writer, playwright, film director, recipient of the National Prize of the GDR
• Jörg Schüttauf (born 1961), actor, recipient of the Grimme-Preis
• Peter Sodann (born 1936), actor, stage director, intendant
• Carina Wiese (born 1968), actress
• Monika Woytowicz (born 1944), actress

• Gerhard Neubauer (ed.): „… dann gehst du aber auf 'ne richtige Schule!“ Fünfzig Jahre Schauspieler-Ausbildung in Leipzig 1953–2003. Hochschule für Musik und Theater „Felix Mendelssohn Bartholdy“, Leipzig 2003.

• Theaterhochschule Leipzig (in German) Leipzig-Lexikon