Thienobenzodiazepine

Thienobenzodiazepine

Thienobenzodiazepine

Class of chemical compounds

Thienobenzodiazepine is a heterocyclic compound containing a diazepine ring fused to a thiophene ring and a benzene ring. Thienobenzodiazepine forms the central core of pharmaceutical drugs including atypical antipsychotic olanzapine (Zyprexa) and antimuscarinic telenzepine. Thienobenzodiazepines act relatively selectively at the α2 subunit of the GABAA receptor.[1]

Not to be confused with thienodiazepine or thienotriazolodiazepine.
General structure of thienobenzodiazepines. Core is highlighted by black and color. Grey depicts accessory functional groups.
General structure of thienobenzodiazepines. Core is highlighted by black and color. Grey depicts accessory functional groups.

References

  1. [1]
    Bymaster, Frank P; Calligaro, David O; Falcone, Julie F; Marsh, Richard D; Moore, Nicholas A; Tye, Nicholas C; Seeman, Philip; Wong, David T (February 1996). "Radioreceptor Binding Profile of the Atypical Antipsychotic Olanzapine". Neuropsychopharmacology. 4 (2): 87–96. doi:10.1016/0893-133X(94)00129-N. PMID 8822531 – via PubMed.


Stub icon

This article about a heterocyclic compound is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article Thienobenzodiazepine, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.