The Treaty of La Pointe may refer to either of two treaties made and signed in La Pointe, Wisconsin between the United States and the Ojibwe (Chippewa) Native American peoples. In addition, the Isle Royale Agreement, an adhesion to the first Treaty of La Pointe, was made at La Pointe.

The first treaty of La Pointe was signed by Robert Stuart for the United States and representatives of the Ojibwe Bands of Lake Superior and the Mississippi River on October 4, 1842 and proclaimed on March 23, 1843, encoded into the laws of the United States as 7 Stat. 591. By this treaty, the Ojibwa ceded extensive tracts of land that are now parts of the states of Wisconsin and Michigan, specifically the latter's Upper Peninsula.

The Webster-Ashburton Treaty was signed on August 9, 1842, between Great Britain and the United States, officially ending their boundary dispute on what now is the Arrowhead Region of Minnesota, as well as settling other claims. This news did not reach the United States parties to the La Pointe Treaty negotiation. Consequently, the Grand Portage Band, then considered to be in Canadian British territory, was not invited to join the signing of this treaty. It is now considered to occupy territory in the United States.

In 1844, the United States and Grand Portage Band signed the Isle Royale Agreement as an adhesion to this treaty.

As determined subsequently by the United States Supreme Court, the signatory tribes retain hunting, fishing and gathering rights on their former lands in this region. In addition, the Supreme Court held that the treaty obligated the United States to provide reservations for peoples of the signatory bands. For instance, it acquired land in the 1930s for the Bay Mills Indian Community, whose people had historically long been located on Lake Superior in Michigan.

The Isle Royale Agreement is an adhesion to the 1842 Treaty of La Pointe, conducted at La Pointe, Wisconsin Territory on August 20, 1844. Commissioner Robert Stuart again represented the United States. The Grand Portage Band was using the resources on Isle Royale and believed it and they were in British territory. After boundary clarification was settled via the Webster Ashburton Treaty of 1842, the Grand Portage Band signed the Isle Royale Agreement with the United States as a treaty adhesion. The 1842 treaty signatories re-affirmed their treaty.

The second treaty of La Pointe was signed by Henry C. Gilbert and David B. Herriman for the United States and representatives of the Ojibwe of Lake Superior and the Mississippi on September 30, 1854, proclaimed on January 29, 1855, and codified as 10 Stat. 1109. The treaty ceded all of the Lake Superior Ojibwe lands to the United States in the Arrowhead Region of Northeastern Minnesota, in exchange for reservations for the Lake Superior Ojibwe in Wisconsin, Michigan, and Minnesota. The signatory tribes retain hunting, fishing and gathering right within this region. The portions left unceded were given claims to the Mississippi Ojibwe. The Indian reservations established under this treaty are:

• L'Anse with Lac Vieux Desert
• Bad River
• Lac du Flambeau and Lac Courte Oreilles
• Fond du Lac
• Grand Portage
• Ontonagon and Red Cliff

along with general land grants to the Metis.

Mole Lake and St. Croix Bands lost their federal recognition due to not being included in this treaty. Mole Lake Band and St. Croix Band's eastern half in Wisconsin re-gained their federal recognition under the Indian Reorganization Act of 1934, but the St. Croix Band's western half in Minnesota are not independently recognized and are considered part of the Mille Lacs Band of Ojibwe.