Four vessels of the United States Navy have been named USS Louisville, after the city of Louisville, Kentucky:

• USS Louisville (1861), was an ironclad steamboat used during the American Civil War
• USS Louisville (ID-1644), was the steamship St. Louis renamed and used in 1918 as a troop transport
• USS Louisville (CA-28), was a heavy cruiser commissioned in 1931 and active in World War II
• USS Louisville (SSN-724), is a Los Angeles-class nuclear attack submarine commissioned in 1986 and decommissioned in March 2021

• Louisville (disambiguation)
• USS St. Louis
• USS Louise

This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.