Ulp1_peptidase

Ulp1 peptidase

Ulp1 peptidase

Class of enzymes

Ulp1 peptidase (EC 3.4.22.68, Smt3-protein conjugate proteinase, Ubl-specific protease 1, Ulp1, Ulp1 endopeptidase, Ulp1 protease) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-!Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3
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The enzyme from Saccharomyces cerevisiae can also recognize small ubiquitin-like modifier 1 (SUMO-1) from human.

References

  1. [1]
    Lima CD, Rawlings ND, Woessner JF (2004). "Ulp1 endopeptidase". In Barrett AJ (ed.). Handbook of Proteolytic Enzymes (2nd ed.). London: Elsevier. pp. 1340–1344.
  2. [2]
    Li SJ, Hochstrasser M (March 1999). "A new protease required for cell-cycle progression in yeast". Nature. 398 (6724): 246–51. doi:10.1038/18457. PMID 10094048.
  3. [3]
    Taylor DL, Ho JC, Oliver A, Watts FZ (March 2002). "Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease". Journal of Cell Science. 115 (Pt 6): 1113–22. PMID 11884512.
  4. [4]
    Li SJ, Hochstrasser M (March 2003). "The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity". The Journal of Cell Biology. 160 (7): 1069–81. doi:10.1083/jcb.200212052. PMC 2172760. PMID 12654900.
  5. [5]
    Ihara M, Koyama H, Uchimura Y, Saitoh H, Kikuchi A (June 2007). "Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growth". The Journal of Biological Chemistry. 282 (22): 16465–75. doi:10.1074/jbc.M610723200. PMID 17428805.
  6. [6]
    Mukhopadhyay D, Dasso M (June 2007). "Modification in reverse: the SUMO proteases". Trends in Biochemical Sciences. 32 (6): 286–95. doi:10.1016/j.tibs.2007.05.002. PMID 17499995.
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