Undecaprenyl-diphosphooligosaccharide---protein_glycotransferase

Undecaprenyl-diphosphooligosaccharide-protein glycotransferase

Undecaprenyl-diphosphooligosaccharide-protein glycotransferase

Class of enzymes

Undecaprenyl-diphosphooligosaccharide-protein glycotransferase (EC 2.4.99.19, PglB) is an enzyme with systematic name tritrans,heptacis-undecaprenyl-diphosphooligosaccharide:protein-L-asparagine N-beta-D-oligosaccharidotransferase.[1][2] This enzyme catalyses the following chemical reaction

tritrans,heptacis-undecaprenyl diphosphooligosaccharide + [protein]-L-asparagine tritrans,heptacis-undecaprenyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to protein L-asparagine
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This is a bacterial enzyme that is isolated from Campylobacter jejuni and Campylobacter lari.

References

  1. [1]
    Maita N, Nyirenda J, Igura M, Kamishikiryo J, Kohda D (February 2010). "Comparative structural biology of eubacterial and archaeal oligosaccharyltransferases". The Journal of Biological Chemistry. 285 (7): 4941–50. doi:10.1074/jbc.M109.081752. PMC 2836098. PMID 20007322.
  2. [2]
    Lizak C, Gerber S, Numao S, Aebi M, Locher KP (June 2011). "X-ray structure of a bacterial oligosaccharyltransferase". Nature. 474 (7351): 350–5. doi:10.1038/nature10151. PMID 21677752. S2CID 205225231.
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