The United States ambassador to Seychelles is the official representative of the government of the United States to the government of Seychelles. The ambassador is concurrently the ambassador to Mauritius, while resident in Port Louis, Mauritius.

• 1 April 1976 - 26 April 1977 Anthony D. Marshall (Resident at Nairobi; Consulate established April 1, 1976)
• 19 July 1977 - 28 June 1980 Wilbert J. LeMelle (Resident at Nairobi)
• 26 August 1980 - 22 September 1983 William Harrop (Resident at Nairobi)
• 2 November 1983 - 9 June 1985 David Joseph Fischer
• 23 August 1985 - 8 July 1987 Irvin Hicks
• 15 December 1987 - 31 August 1991 James B. Moran
• 1 October 1991 - 5 July 1992 Richard W. Carlson
• 22 September 1992 - 1 March 1993 Mack F. Mattingly
• 1 March 1993 - 7 September 1994 F. Stephen Malott (Chargé d'affaires)
• 7 September 1994 - 12 May 1995 Carl B. Stokes
• 12 May 1995 - 29 August 1996 Brent E. Blaschke (Chargé d'affaires)
• 29 August 1996 - 27 May 1999 Harold W. Geisel (Resident at Mauritius)
• 14 September 1999 - 4 March 2001 Mark Wylea Erwin (Resident at Mauritius)
• 17 July 2002 - 22 June 2005 John Price (Resident at Mauritius)
• 2 October 2006 - 14 October 2009 Cesar B. Cabrera (Resident at Mauritius)
• 18 February 2010 - 26 February 2011 Mary Jo Wills (Resident at Mauritius)
• 5 November 2012 - 20 January 2017 Shari Villarosa (Resident at Mauritius)
• 6 February 2018 - 15 January 2021 David Dale Reimer (Resident at Mauritius)
• 21 March 2023 - Present Henry V. Jardine (Resident at Mauritius)

• Seychelles – United States relations
• Foreign relations of Seychelles
• Ambassadors of the United States

• United States Department of State: Background notes on Seychelles
•  This article incorporates public domain material from U.S. Bilateral Relations Fact Sheets. United States Department of State.

• United States Department of State: Chiefs of Mission for the Seychelles
• United States Department of State: Seychelles
• United States Embassy in Port Louis