Upjohn was a pharmaceutical firm.

Upjohn, as a surname, is a patronymic name derived from the Welsh "ap Siôn" meaning "son of John". It may refer to:

• Gerald Upjohn, Baron Upjohn (1903–1971), a soldier and judge
• Hobart Upjohn (1876–1949), an architect
• Ian Upjohn, barrister
• Richard M. Upjohn (1828–1903), architect
• Richard Upjohn Light (1902–1994), a neurosurgeon, aviator, cinematographer and geographer
• Richard Upjohn (1802–1878), an English-born architect
• William E. Upjohn (1853–1932), a medical doctor
• William George Dismore Upjohn (1888–1979), a surgeon

• Aubrey Upjohn, fictional character in the Jeeves novels by P. G. Wodehouse
• Bronn (character), in Game of Thrones Season 6 episode 7 ("The Broken Man"), describes himself to Jaime Lannister as "an upjohn sellsword"
• Mrs. Emily Upjohn, a character in the Marx Brothers' film A Day at the Races

• Upjohn Co. v. United States, 449 U.S. 383 (1981), a Supreme Court case
• Upjohn dihydroxylation, an organic reaction which converts an alkene to a cis vicinal diol
• Upjohn's Triangle of Health, a short-lived series of animated short films produced in late 1960s and again in late 1970s by The Walt Disney Company's educational media division
• W. E. Upjohn Institute for Employment Research, an American independent research organization based in Kalamazoo, Michigan

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