Urate-ribonucleotide_phosphorylase

Urate-ribonucleotide phosphorylase

Urate-ribonucleotide phosphorylase

Enzyme in purine metabolism

In enzymology, an urate-ribonucleotide phosphorylase (EC 2.4.2.16) is an enzyme that catalyzes the chemical reaction

urate D-ribonucleotide + phosphate urate + alpha-D-ribose 1-phosphate
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Thus, the two substrates of this enzyme are urate D-ribonucleotide and phosphate, whereas its two products are urate and alpha-D-ribose 1-phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is urate-ribonucleotide:phosphate alpha-D-ribosyltransferase. Other names in common use include UAR phosphorylase, and urate-ribonucleotide:phosphate D-ribosyltransferase. This enzyme participates in purine metabolism.

References

    • Laster L, Blair A (October 1963). "An intestinal phosphorylase for uric acid ribonucleoside". The Journal of Biological Chemistry. 238: 3348–57. PMID 14085385.


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