The Viceroy of Yun-Gui, fully in Chinese as the Governor-General of Yun-Gui Provinces and Other Local Areas, in Charge of Military Affairs, Food and Wages and Governor Affairs, was one of eight regional Viceroys during the Qing dynasty of China. The Viceroy of Yun-Gui had jurisdiction of military, civil, and political affairs over then Yunnan Province and then Guizhou Province (approx. nowadays southern part of Yunnan and part of Guizhou).

The Viceroy of Yun-Gui was created in 1659, during the reign of the Shunzhi Emperor, as a jinglue (經略; military governor) office before it was converted to a Viceroy.

In 1662, during the reign of the Kangxi Emperor, the Viceroy of Yun-Gui split into the Viceroy of Yunnan and Viceroy of Guizhou, which were respectively headquartered in Qujing and Anshun. Two years later, the two viceroys were merged and the headquarters shifted to Guiyang. In 1673, the Kangxi Emperor restored the Viceroy of Yunnan, with its headquarters in Qujing. Between 1673 and 1681, the Revolt of the Three Feudatories broke out in Yunnan, Guangdong and Fujian provinces. The Viceroy of Yun-Gui was restored in 1680.

In 1728, the Yongzheng Emperor put the Viceroy of Yun-Gui in charge of Guangxi Province as well but reversed the changes in 1734. This system lasted until the fall of the Qing dynasty in 1912.

Starting from 1905, during the reign of the Guangxu Emperor, the Viceroy of Yun-Gui concurrently held the appointment of Provincial Governor of Yunnan.