WAY-100135
WAY-100135
Chemical compound
WAY-100135 is a serotonergic drug of the phenylpiperazine family which is used in scientific research.[1] It acts as potent 5-HT1A receptor antagonist,[2] and was originally believed to be highly selective, but further studies have demonstrated that it also acts as a partial agonist of the 5-HT1D receptor (pKi = 7.58; virtually the same affinity for 5-HT1A), and to a much lesser extent, of the 5-HT1B receptor (pKi = 5.82).[3] These findings may have prompted the development of the related compound WAY-100635, another purportedly selective and even more potent 5-HT1A antagonist, which was synthesized shortly thereafter.[4] However, WAY-100635 turned out to be non-selective as well, having been shown to act additionally as a potent D4 receptor agonist later on.[5]